三、主要科研工作与成绩 代表性主持的科研项目: 1)国家重点研发子课题：果蔬中典型农药残留混合污染联合效应评价及应用，149万2018.12-2021.12 3)农业部项目：果蔬产品抗生素残留排查及其风险评估，40万，2022.03-2022.12 4)浙江省科技计划项目：果蔬中几种高风险内分泌干扰物类农药复合效应评估及预警技术研究，80万，2016.01-2018.11 5)浙江省农业农村厅项目：浙江省鲜活水产品中地西泮的残留代谢及迁移规律及风险评估研究，78万，2022.05-2024.01 7)浙江省财政重大专项：厅级项目：特色农产品全产业链安全风险管控（“一品一策”），1200万，2017.01-2017.12 8)湘湖实验室自设重点项目：细胞外囊泡调控宿主健康的机制及应用研究，300万，2023.01-2024.12 9)横向：龙泉灵芝(黑木耳)全产业链质量提升关键技术研究，280万，2024.12-2026.12 10）横向：高功效牛初乳产品创制，150万，2025.03-2026.03 奖励和荣誉： 1)“浙江主要特色农产品安全控制关键技术研究与应用”，2016-2018年度全国农牧渔业丰收奖一等奖，排名第3。 2)“有机肥料提质增效安全利用关键技术”，浙江省科技进步奖二等奖，排名第4 6)“浙江主要特色农产品安全监控关键技术研究与应用”，2020年度省科技进步奖三等奖，排名第3 7)“有机肥提质增效安全使用技术研究与应用”，2021年度农业农村厅农业科技进步一等奖，排名第3 代表性标准： 1)国家行业标准：枇杷生产技术规程，NY/T 3847-2021 2)国家行业标准：猕猴桃主要病虫害防治技术规程，NY/T3861-2021 3)国家行业标准：茭白生产技术规程，NY/T2723-2015 代表性文章： JintaoCheng, Jiali Chen, Dingfeng Chen, Baoxian Li, Chaozhi Wei, TaoLiu, Xiao Wang, Zhengshun Wen, Yuanxiang Jin, Chenfan Sun*,GuilingYang*,2025,Development of a Komagataella phaffii cell factory forsustainable production of (+)-valencene. Microbial CellFactories, 24(1), 29. IF=4.3（2025） JintaoCheng,JialiChen, Dingfeng Chen, Baoxian Li, Zhengshun Wen,Yuanxiang Jin,Chenfan Sun,GuilingYang,2025, Development of Komagataella phaffii as a cell factory forefficient de novo production of β-caryophyllene. NewBiotechnology, 85, 52-58. IF=4.6（2025） JintaoCheng*,ZhongjiPu,JialiChen, Dingfeng Chen, Baoxian Li, Zhengshun Wen, Yuanxiang Jin,YanlaiYao, Kan Shao,XiaosongGu*,GuilingYang*,2025, Development of a green Komagataella phaffii cell factoryfor sustainable production of plant-derived sesquiterpene(–)-α-bisabolol. Synthetic and Systems Biotechnology, 10(1),120-126. IF=4.8（2025） ChaozhiWei, Mengyu Zhang, Jintao Cheng, Jinzhong Tian, GuilingYang*,Yuanxiang Jin*.Plant-derived exosome-like nanoparticles – from Laboratory tofactory, a landscape of application, challenges andprospects. Critical Reviews in Food Science and Nutrition,2024,August, 1–19,IF=7.3（2024） JailiLi, Ting Luo, Yao Zhao, Dou Wang, Yuanxiang Jin, Zufang Wu*,GuilingYang*,Xingjiang Qi*,Cardioprotective potentials of myricetin on doxorubicin-inducedcardiotoxicity based on biochemical and transcriptomic analysis,Biomedicine & Pharmacotherapy, Volume 175, 2024, 116748,ISSN 0753-3322.IF=6.9（2024） JinlingLi, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, GuilingYang*,Xin Zhang*.2024. Therapeutic application and potential mechanism ofplant-derived extracellular vesicles in inflammatory boweldisease. Journal of advanced research,S2090-1232(24)00047-X. Advance online publication. IF=11.4（2024） WeitaoWang, Ting Luo, Yao Zhao, Xinyuan Yang, Dou Wang, GuilingYang*,Yuanxiang Jin*. 2024. Antibiotic resistance gene distribution inShine Muscat grapes and health risk assessment of streptomycinresidues in mice. Journal of hazardous materials, 465, 133254. IF=12.2（2024） XianghaiZhu, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin*, GuilingYang*.2023. The occurrence of typical psychotropic drugs in theaquatic environments and their potential toxicity to aquaticorganisms - A review. The Science of the total environment, 900,165732. IF=9.8（2023） ZhiweiBao, Dou Wang, Yao Zhao, Ting Luo, Guilin Yang*, Yuanxiang Jin*.2023. Insights into enhanced toxic effects by the binary mixtureof carbendazim and procymidone on hepatic lipid metabolism inmice. Science of the Total Environment 882. Elsevier B.V.2023.163648. IF=9.8（2023） YutingDu, Qiang Wang, GuilingYang*,and Fuliang Han*. 2022. Determination of 43 pesticide residuesin intact grape berries (Vitis Vinifera L.) by using anultrasound-assisted acetonitrile extraction method followed byLC–MS/MS. Food Control 140. Elsevier Ltd. 2022.109123. IF=6.652（2022） TingLuo, Dou Wang, Yao Zhao, Xinfang Li, GuilingYang*,Yuanxiang Jin. 2022. Polystyrene microplastics exacerbateexperimental colitis in mice tightly associated with theoccurrence of hepatic inflammation. Science of the TotalEnvironment 844. Elsevier B.V. 2022.156884. IF=10.753（2022） ZhenQin, Weitao Wang, You Weng, Zhiwei Bao, GuilingYang*, Yuanxiang Jin*. 2022. Bromuconazole exposure inducescardiotoxicity and lipid transport disorder in larval zebrafish.Comparative Biochemistry and Physiology Part - C: Toxicology andPharmacology 262. Elsevier Inc. 2022.109451. IF=4.52（2022） GuilingYang#,Yanhua Wang#, Tiancai Wang, Dou Wang, Hongbiao Weng, Qiang Wang,Chen Chen*. 2021. Variations of enzymatic activity and geneexpression in zebrafish (Danio rerio) embryos co-exposed tozearalenone and fumonisin B1. Ecotoxicology and EnvironmentalSafety 222. Academic Press. IF=6.29（2021） GuilingYang,You Weng, Yao Zhao, Dou Wang, Ting Luo, Yuanxiang Jin*. 2022.Transcriptomic and targeted metabolomic analysis revealed thetoxic effects of prochloraz on larval zebrafish. Science of theTotal Environment 822. Elsevier B.V. IF=10.753（2022） DouWang#, GuilingYang#,Xiao Yun, Ting Luo, Hao Guo, Liying Pan, Wei Du, et al. 2024.Carbendazim residue in plant-based foods in China: Consecutivesurveys from 2011 to 2020. Environmental Science andEcotechnology 17. Editorial Board, Research of EnvironmentalSciences. IF=12.6（2024）
代表性著作： 1)营养元素及相关物质最高摄入量模型构建，中国农业出版社，2020，主译 2)葡萄全产业链质量安全风险管控，中国农业出版社，2018，主编 代表性专利： 1)一种农产品质量安全指数确定方法及系统，ZL2020 10608947.6 2)室温条件下草莓表面鼠伤寒沙门氏菌预测模型及其建立方法，ZL201610488762.X 3)一种莲藕重金属富集系数预测系统，荷兰专利：N2031259 |
