三、主要科研工作与成绩 一、主要科研项目: 上海市重点团队建设项目(2024ZDXK0030),50万,负责人 国家自然科学基金面上项目(82271388):Porf-2介导视神经损伤后无长突细胞Zn2+失稳态影响视网膜神经节细胞存活和轴突再生的机制研究(2023.01-2026.12),52万,负责人 国家自然科学基金面上项目(81772059):Porf-2调控EphB3/EphrinB3细胞间信号传导影响视神经损伤后轴突再生的分子机制(2018.01-2021.12),56万,负责人 国家自然科学基金面上项目(81372047):CRMP-2调控弥漫性轴索损伤后海马Aβ表达及学习记忆功能的机制研究(2014.1 2017.12),70 ,负责人 国家自然科学基金面上项目(81171796):Porf-2调控Wnt通路的分子机制及对视神经损伤后神经干细胞增殖分化的影响(2012.1 2015.12),58 ,负责人 国家科技部重点研发计划(2016YFC0106104)项目:导航微创神经外科手术集成解决方案应用示范基地建设2,200 ,负责人
二、主要论文: PanYB#, Zhang CH#, Wang SQ#, Ai PH, Chen K, Zhu L, Sun ZL, Feng DF*.Transforming growth factor beta induced (TGFBI) is a potentialsignature gene for mesenchymal subtype high-grade glioma. JNeurooncol, 2018, 137(2); 395-407 HuangGH# ,Guo L# ,Zhu L , Liu XD, Sun ZL , Li HJ , Xu NJ*, Feng DF*.Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axongrowth. Cell Mol Life Sci, 2018, 75(22); 4207-4222 HuangGH#, Chen K, Sun YY, Zhu L, Sun ZL, Feng DF*. 4-Phenylbutyrateameliorates anxiety disorder by inhibiting endoplasmic reticulumstress following diffuse axonal injury. Journal of neurotrauma,2019, 36(11), 1856-1868 LiHJ#, Sun ZL#, Pan YB, Xu MH, Feng DF*.Effect of α7nAChR onlearning and memory dysfunction in a rat model of diffuse axonalinjury. Experimental cell research, 2019, 383(2), 111546. LiHJ#, Sun ZL, Pan YB, Sun YY, Xu MH, Feng DF*.Inhibition ofmiRNA-21 promotes retinal ganglion cell survival and visualfunction by modulating Müller cell gliosis after optic nervecrush. Experimental cell research, 2019, 375(2), 10-19. ChenK#, Gu H#, Zhu L# , Feng DF* .A New Model of Repetitive TraumaticBrain Injury in Mice. Frontiers in Neuroscience,2020,13,1417. HuangGH#, Li XC# , Ren L , Dai RX , Sun ZL , Jiang XF* , Feng DF*.Take it seriously or not: postoperative pneumocephalus in CSDHpatients? British journal of neurosurgery, 2020, 34(3), 284-289. SunYY# , Zhu L# , Sun ZL , Feng DF*. CRMP2 improves memory deficitsby enhancing the maturation of neuronal dendritic spines aftertraumatic brain injury. Experimental neurology, 2020, 328,113253. ChenK# , Zhu L# , Guo L , Pan YB , Feng DF*.Maf1 regulates dendriticmorphogenesis and influences learning and memory. Cell death &disease, 2020, 11(7), 606. PanYB#, Sun YY#, Li HJ#, Zhou LY, Zhang JM*, Feng DF*. TranscriptomeAnalyses Reveal Systematic Molecular Pathology After Optic NerveCrush. Frontiers in Cellular Neuroscience. 2022,15,800154 ChenD#, Sun YY#, Zhou LY, Yang S, Hong FY, Liu XD, Sun ZL, Huang J*,Feng DF*. Maf1 regulates axonal regeneration of retinal ganglioncells after injury. Experimental Neurology.2022,348,113948. ZhengRZ#, Xu CX, Zhou LY, Feng DF*. Default mode network overshadowexecutive control network in coma emergence and awakeningprediction of patients with sTBI. Neuroimage Clin. 2023;37:103361 ZhouLY#, Chen D#, Guo XR, Niu YQ, Xu YS, Feng DF*, Li TC*.Intravitreal injection of Huperzine A promotes retinal ganglioncells survival and axonal regeneration after optic nerve crush.Front Cell Neurosci. 2023 May 24;17:1145574 ChenD#, Sun YY#, Zhou LY#, Han X, Yang S, Hong FY, Yuan Y, Wu XH,Huang GH, Cheng YC, Huang J*, Feng DF*. Knockdown of Porf-2restores visual function after optic nerve crush injury. CellDeath Dis. 2023 Aug 28;14(8):570 ShiMG#, Feng XM, Zhi HY, Hou L, Feng DF*. Machine learning-basedradiomics in neurodegenerative and cerebrovascular disease.MedComm (2020). 2024 Oct 28;5(11):e778.
三、专利 1.一种产生啮齿类动物弥漫性轴索损伤的装置 2.一种防辐射材料 3.一种用于治疗神经损伤疾病的基因药物 4.可同时产生瞬时超大角加速度和线加速度的装置 5.一种新型鼻饲系统 6.小动物头部固定装置 |